Physical training program for people at risk of cardiovascular disorders in the primary care setting: A randomized clinical trial.

BACKGROUND AND OBJECTIVE: The impact of a physical training program on moderate-vigorous physical activity is still poorly known in primary cardiovascular prevention. Our objective was to determine the efficacy of a physical training program to promote moderate-vigorous physical activity and exercise in individuals at risk of suffering a cardiovascular event. PATIENTS AND METHODS: Randomized, parallel group controlled trial performed from October 2014 to July 2016. Sedentary patients at risk of suffering a cardiovascular event were randomized to the control group (CG) (72) or the intervention group (IG) (75). Intervention consisted of a 2-month physical training program. The main outcome was the proportion of patients achieving a "relevant response to Physical Activity" (increase≥240METs-min/week in moderate-vigorous Physical Activity using the International Physical Activity Questionnaire (IPAQ)). Secondary outcomes included the proportion of patients performing an "adequate amount of exercise" (≥360METs-min/week in moderate-vigorous exercise using the IPAQ). RESULTS: Of the 147 patients randomized, 132 (90%) completed the follow-up. Adherence to exercise performance was 91% and no adverse effects were recorded. The proportion of patients in the IG versus CG achieving the main outcome was 34.9% vs 11.6%; OR [95%CI]: 4.2 [1.7-10.4]. Furthermore, more patients in the IG performed an adequate amount of exercise (33.3% vs. 11.6%; OR: 4.1 [1.6-10.5]). CONCLUSION: A short-duration physical training program performed in the primary care setting is efficacious and safe in promoting moderate-vigorous physical activity and exercise in the short-term, in a population at risk of suffering a cardiovascular event. TRIAL REGISTRATION: "Training Programme in Physical Activity". NCT03717363. TRIAL REGISTRATION: Clinicaltrials.gov.

Prevalence of hypertension and other cardiovascular risk factors in subjects with subclinical hypothyroidism. / Prevalencia de hipertensión arterial y otros factores de riesgo cardiovascular en la población con hipotiroidismo subclínico.

BACKGROUND AND OBJECTIVE: To assess the prevalence of hypertension, diabetes, and dyslipidaemia in subjects with subclinical hypothyroidism (SH) in comparison with an age- and sex-matched control group. PATIENTS AND METHODS: Case-control study with 240 subjects with SH and 480 controls carried out on patients aged 35-75 years admitted to a Primary Care Centre. The prevalence of hypertension, diabetes and dyslipidaemia, as well as blood pressure, plasma glucose, and lipid profilses, were evaluated in both groups. RESULTS: No differences were observed neither in the prevalence of hypertension (34.2% vs. 29.6%) or diabetes (12.1% vs. 10%) nor in mean values of blood pressure or plasma fasting glucose. Subjects with SH had an increased prevalence of lipid abnormalities (72.1% vs. 57.7%; P<.001), and increased mean values of total cholesterol (205±34 vs. 193±35mg/dL; P<.001), compared to the control group. CONCLUSION: Patients with SH have an increased prevalence of lipid abnormalities. This can be responsible for an increased cardiovascular risk in such patients.